RT info:eu-repo/semantics/article
T1 Functional EEG network analysis in schizophrenia: Evidence of larger segregation and deficit of modulation
A1 Gómez Pilar, Javier
A1 Lubeiro Juárez, Alba
A1 Poza Crespo, Jesús
A1 Hornero Sánchez, Roberto
A1 Ayuso, Marta
A1 Valcarcel, César
A1 Haidar, Mahmoun-Karim
A1 Blanco Garrote, José Antonio
A1 Molina Rodríguez, Vicente
AB Objective: Higher mental functions depend on global cerebral functional coordination. Our aim was to study fastmodulation of functional networks in schizophrenia that has not been previously assessed.Methods: Graph-theory was used to analyze the electroencephalographic (EEG) activity during an odd-ball taskin 57 schizophrenia patients (18 first episode patients, FEPs) and 59 healthy controls. Clustering coefficient(CLC), characteristic path length (PL) and small-worldness (SW) were computed at baseline ([−300 0] ms priorto stimulus delivery) and response ([150 450] ms post-stimulus) windows. Clinical and cognitive assessmentswere performed.Results: CLC, PL and SW showed a significant modulation between baseline and response in controls but not inpatients. Patients obtained higher CLC and SW at baseline, lower CLC and higher PL at response, and diminishedmodulation of CLC and SW as compared to controls. In patients, CLC and SW modulation were inverselyassociated to cognitive performance in executive tasks and directly associated to working memory. Similarpatterns were observed in FEPs. CLC and SW during the baseline were inversely associated to their respectivemodulation magnitudes.Conclusions: Our results are coherent with a hyper-segregated network at baseline (higher CLC) and a decreasedmodulation of the functional connectivity during cognition in schizophrenia.
PB Elsevier
YR 2017
FD 2017
LK http://uvadoc.uva.es/handle/10324/31345
UL http://uvadoc.uva.es/handle/10324/31345
LA eng
NO Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 76, pp. 116-123, 2017.
DS UVaDOC
RD 27-nov-2024