RT info:eu-repo/semantics/conferenceObject
T1 Phase-Amplitude Coupling Analysis of Spontaneous EEG Activity in Alzheimer’s Disease
A1 Poza Crespo, Jesús
A1 Bachiller Matarranz, Alejandro
A1 Gómez Peña, Carlos
A1 García, María
A1 Núñez Novo, Pablo
A1 Gómez Pilar, Javier
A1 Tola Arribas, Miguel Ángel
A1 Cano, Mónica
A1 Hornero Sánchez, Roberto
AB This study was aimed at exploring phaseamplitudecoupling (PAC) patterns of neural activity indementia due to Alzheimer’s disease (AD). For this task, fiveminutes of spontaneous electroencephalographic (EEG) activityfrom 22 patients with mild AD and 16 cognitively healthycontrols were studied. To assess PAC patterns, phase-lockingvalue was computed between the phase of low frequencies andthe power of high frequencies within each sensor. Our resultsshowed that high-frequency gamma power is phase-locked tothe alpha peak in EEG signals. Furthermore, statisticallysignificant differences (p<0.05, permutation test) betweenpatients with mild AD and elderly controls were observed atthe lower left temporo-parietal area, suggesting that earlystages of AD elicit a region-specific decrease of PAC in theneural activity.
YR 2017
FD 2017
LK http://uvadoc.uva.es/handle/10324/31353
UL http://uvadoc.uva.es/handle/10324/31353
LA eng
NO Producción Científica
DS UVaDOC
RD 18-nov-2024