RT info:eu-repo/semantics/article
T1 Optimized Diffusion-Weighting Gradient Waveform Design (ODGD) formulation for motion compensation and concomitant gradient nulling
A1 Peña Nogales, Óscar
A1 Zhang, Yuxin
A1 Wang, Xiaoke
A1 Luis García, Rodrigo de
A1 Aja Fernández, Santiago
A1 H. Holmes, James
A1 Hernando, Diego
K1 Diffusion-weighted imaging (DWI)
K1 diffusion-weighting gradient waveforms
K1 optimization
K1 motion compensation
K1 concomitant gradient (CG)-nulling
AB Purpose: To present a novel Optimized Diffusion-weighting Gradient waveform Design (ODGD) method for the design of minimum echo time (TE), bulk motion-compensated, and concomitant gradient (CG)-nulling  waveforms for diffusion MRI.Methods: ODGD motion-compensated waveforms were designed for various moment-nullings Mn (n=0,1,2), for a range of b-values, and spatial resolutions, both without (ODGD-Mn) and with CG-nulling (ODGD-Mn-CG). Phantom and in-vivo (brain and liver) experiments were conducted with various ODGD waveforms to compare motion robustness, signal-to-noise ratio (SNR), and apparent diffusion coefficient (ADC) maps with state-of-the-art waveforms.Results:ODGD-Mn and ODGD-Mn-CG waveforms reduced the TE of state-of-the-art waveforms. This TE reduction resulted in significantly higher SNR (P < 0.05) in both phantom and in-vivo experiments. ODGD-M1 improved the SNR of BIPOLAR (42.8+-5.3 versus 32.9+-3.3) in the brain, and ODGD-M2 the SNR of motion-compensated (MOCO) and Convex Optimized Diffusion Encoding-M2 (CODE-M2) (12.3+-3.6 versus 9.7+-2.9 and 10.2+-3.4, respectively) in the liver. Further, ODGD-M2 also showed excellent motion robustness in the liver. ODGD-M2-CG waveforms reduced the CG-related dephasing effects of non CG-nulling waveforms in phantom and in-vivo experiments, resulting in accurate ADC maps.Conclusions: ODGD waveforms enable motion-robust diffusion MRI with reduced TEs, increased SNR, and reduced ADC bias compared to state-of-the-art waveforms in theoretical results, simulations, phantoms and in-vivo experiments.
PB Wiley
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/31374
UL http://uvadoc.uva.es/handle/10324/31374
LA eng
NO Magn. Reson. Med 2018;00:1-15
NO Producción Científica
DS UVaDOC
RD 22-nov-2024