RT info:eu-repo/semantics/conferenceObject T1 Optimal Diffusion-weighting Gradient Waveform Design (ODGD): Formulation and Experimental Validation A1 Peña Nogales, Óscar A1 Zhang, Yuxin A1 Luis García, Rodrigo de A1 Aja Fernández, Santiago A1 H. Holmes, James A1 Hernando, Diego AB Diffusion-Weighted MRI often suffers from signal attenuation due to long TE, sensitivity to physiological motion, and dephasing due to concomitant gradients (CGs). These challenges complicate image interpretation and may introduce bias in quantitative diffusion measurements. Motion moment-nulled diffusion-weighting gradients have been proposed to compensate motion, however, they frequently result in high TE and suffer from CG effects. In this work, the Optimal Diffusion-weighting Gradient waveform Design method that overcomes limitations of state-of-the-art waveforms is revisited and validated in phantom and in-vivo experiments. These diffusion-weighting gradient waveforms reduce the TE and increase the SNR of state-of-the-art waveforms without and with CG-nulling. YR 2018 FD 2018 LK http://uvadoc.uva.es/handle/10324/31375 UL http://uvadoc.uva.es/handle/10324/31375 LA eng NO International Society of Magnetic Resonance in Medicine 26th Annual, Paris,2018 DS UVaDOC RD 22-dic-2024