RT info:eu-repo/semantics/article
T1 Production of copper loaded lipid microparticles by PGSS® (particles from gas saturated solutions) process
A1 Martín, Victor
A1 Gonçalves, Vanessa Santos Silva
A1 Rodríguez Rojo, Soraya
A1 Nunes, Daniela
A1 Fortunato, Elvira
A1 Martins, Rodrigo
A1 Cocero Alonso, María José
A1 Duarte, Catarina M.M.
K1 PGSS
K1 Copper nanoparticles encapsulation
K1 Lipid microparticles
K1 Dispersion
AB Production of lipid particles loaded with metal nanoparticles by supercritical fluids based processes has been barely studied. In this work, copper nanoparticles were loaded into glyceryl palmitostearate microparticles by PGSS® (Particles from Gas Saturated Solutions). The effect of different variables, temperature (60-80 ºC), copper load (0.2-5%w/w) and water addition (0 – 40%w/w), in particle size and encapsulation efficiency has been studied. The dispersion of metal nanoparticles in the lipid has been determined by SEM-FIB coupled with EDS mapping. In all cases, mean particle size values lower than 70 μm have been obtained, and encapsulation efficiencies around 60% have been achieved. The addition of water has no negative effect in encapsulation efficiency nor in nanoparticles dispersion within the lipid microparticle, being important since nanoparticles are commonly synthetized in aqueous medium.
PB Elsevier B.V.
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/31443
UL http://uvadoc.uva.es/handle/10324/31443
LA eng
NO The Journal of Supercritical Fluids, 2018, vol.131, p. 124–129.
DS UVaDOC
RD 08-nov-2024