RT info:eu-repo/semantics/masterThesis
T1 Evaluation of the role of Meis 2 during inner ear formation and morphogenesis
A1 Calvo Ibáñez, Sara
A2 Universidad de Valladolid. Facultad de Medicina
K1 Meis 2
K1 Morfogénesis
AB Meis genes are vertebrate orthologues of the Drosophila homolog homothorax (hth) genewhich encode for transcription factors belonging to a subfamily of TALE proteins. Inmammals, TALE superclass comprises two families: PBC (Pbx1-4 genes) and MEINOX,this latter including the PREP (Prep1-2 genes) and MEIS (Meis1-3 genes) sub-families(Schulte, 2014).TALE (Three Aminoacid Loop Extension) proteins receive their name from the sharedfeature of a proline-tyrosine-proline motive insertion between the first and second helix ofthe highly conserved helix-loop-helix homeodomain. (Longobardi et al., 2014) Thishomeodomain is around 60 amino acids long and allows TALE proteins to bind to DNA,thus conferring them the ability to act as transcription factors. (Mukherjee and Bürglin,2007). Additionally, these proteins contain protein-protein interaction domains in theiramino-terminal regions that permit them to form complexes with other transcriptionfactors.While the homeodomain is conserved throughout the members of the TALE class, theseamino-terminus regions are family specific: PBX family possess PBC-A and PBC-Bdomains while the MEIS-A and MEIS-B domains are present in the PREP and MEISsubfamilies
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/31622
UL http://uvadoc.uva.es/handle/10324/31622
LA spa
DS UVaDOC
RD 24-nov-2024