RT info:eu-repo/semantics/article
T1 Highly enantioselective addition of dimethylzinc to fluorinated alkyl ketones, and the mechanism behind it
A1 Neves García, Tomaz
A1 Vélez Blasco, Andrea
A1 Martínez de Ilarduya Martínez de Ilarduya, Jesús María
A1 Espinet Rubio, Pablo
K1 Química organometálica
K1 Organometallic chemistry
AB Chiral-diamine catalyzed addition of ZnMe2 to PhC(O)CF2X (in dichloromethane at −30 °C) affords fluorinated alkyl tertiary alcohols in high yield (quantitative for X = H, F, Cl; 84% for X = CF3) and up to 99% ee. These conditions are similarly very efficient for other various ArC(O)CF3 molecules. A fine analysis of the results can be performed based on a double-cycle mechanism.
PB Royal Society of Chemistry
SN 1359-7345
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/32631
UL http://uvadoc.uva.es/handle/10324/32631
LA eng
NO Chemical Communications, 2018,54, 11809-11812
NO Producción Científica
DS UVaDOC
RD 27-dic-2024