RT info:eu-repo/semantics/article
T1 Random and oriented electrospun fibers based on a multicomponent, in situ clickable elastin-like recombinamer system for dermal tissue engineering
A1 González de Torre, Israel
A1 Ibáñez Fonseca, Arturo
A1 Quintanilla Sierra, Luis
A1 Alonso Rodrigo, Matilde
A1 Rodríguez Cabello, José Carlos
K1 Elastina
K1 Ingeniería de tejidos dérmicos
K1 Elastin
K1 Dermal tissue engineering
AB Herein we present a system to obtain fibers from clickable elastin-like recombinamers (ELRs) that crosslink in situ during the electrospinning process itself, with no need for any further treatment to stabilize them. These ELR-click fibers are completely stable under in vitro conditions. A wrinkled fiber morphology is obtained. In addition to a random fiber orientation, oriented fibers with a high degree of alignment and coherence can also be obtained by using a rotational electrode. The production of multicomponent fibers means that different functionalities, such as cell-adhesion domains (RGD peptides), can be incorporated into them. In a subsequent study, two main cell lines present in the dermis and epidermis, namely keratinocytes and fibroblasts, were cultured on top of the ELR-click fibers. Adhesion, proliferation, fluorescence, immunostaining and histology studies showed the cytocompatibility of these scaffolds, thus suggesting their possible use for wound dressings in skin tissue engineering applications.
PB Elsevier
SN 1742-7061
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/33443
UL http://uvadoc.uva.es/handle/10324/33443
LA eng
NO Acta Biomaterialia, 2018,  Volume 72, Pages 137-149
NO Producción Científica
DS UVaDOC
RD 19-abr-2024