RT info:eu-repo/semantics/article
T1 Bioactive scaffolds based on elastin-like materials for wound healing
A1 Rodríguez Cabello, José Carlos
A1 González de Torre, Israel
A1 Ibáñez Fonseca, Arturo
A1 Alonso Rodrigo, Matilde
K1 Elastina
K1 Elastin
AB Wound healing is a complex process that, in healthy tissues, starts immediately after the injury. Even though it is a natural well-orchestrated process, large trauma wounds, or injuries caused by acids or other chemicals, usually produce a non-elastic deformed tissue that not only have biological reduced properties but a clear aesthetic effect. One of the main drawbacks of the scaffolds used for wound dressing is the lack of elasticity, driving to non-elastic and contracted tissues. In the last decades, elastin based materials have gained in importance as biomaterials for tissue engineering applications due to their good cyto- and bio-compatibility, their ease handling and design, production and modification. Synthetic elastin or elastin like-peptides (ELPs) are the two main families of biomaterials that try to mimic the outstanding properties of natural elastin, elasticity amongst others; although there are no in vivo studies that clearly support that these two families of elastin based materials improve the elasticity of the artificial scaffolds and of the regenerated skin. Within the next pages a review of the different forms (coacervates, fibres, hydrogels and biofunctionalized surfaces) in which these two families of biomaterials can be processed to be applied in the wound healing field have been done. Here, we explore the mechanical and biological properties of these scaffolds as well as the different in vivo approaches in which these scaffolds have been used.
PB Elsevier
SN 0169-409X
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/33446
UL http://uvadoc.uva.es/handle/10324/33446
LA eng
NO Advanced Drug Delivery Reviews, 2018, Volume 129, Pages 118-133
NO Producción Científica
DS UVaDOC
RD 22-nov-2024