RT info:eu-repo/semantics/article
T1 Self-Assembling Elastin-Like Hydrogels for Timolol Delivery: Development of an Ophthalmic Formulation Against Glaucoma
A1 Fernández Colino, Alicia
A1 Quinteros, Daniela A.
A1 Girotti, Alessandra
A1 Palma, Santiago D.
A1 Arias Vallejo, Francisco Javier
K1 Glaucoma
K1 Elastina
K1 Elastin
AB This work focuses on improving the effectiveness of current therapies against glaucoma by incorporating self-assembled polymers into the ophthalmic formulation. To that end, we first studied the influence of the dispersing medium on the mechanical performance of self-assembling elastin-like (EL) and silk-elastin-like (SEL) hydrogels by conducting rheological tests. These polymers were subsequently incorporated into the antiglaucoma formulation, which contains timolol maleate (TM) as active ingredient, and in vivo tests, namely adhesion tests and intraocular pressure measurements (IOP), were performed in New Zealand rabbits. An enhanced reduction in IOP due to the presence of the polymers was observed. Moreover, differences in the effectiveness between both EL- and SEL-hydrogels, which can be explained on the basis of the different rheological properties displayed by these two systems, were also encountered. The results point to the potential of this system as a basis for the development of an ophthalmic formulation against glaucoma.
PB American Chemical Society
SN 1543-8384
YR 2017
FD 2017
LK http://uvadoc.uva.es/handle/10324/33506
UL http://uvadoc.uva.es/handle/10324/33506
LA eng
NO Molecular Pharmaceutics, 2017, 14 (12), pp 4498–4508
NO Producción Científica
DS UVaDOC
RD 24-nov-2024