RT info:eu-repo/semantics/article
T1 A transferrin receptor-binding mucoadhesive elastin-like recombinamer: In vitro and in vivo characterization
A1 González Obeso, Constancio
A1 Girotti, Alessandra
A1 Rodríguez Cabello, José Carlos
K1 Receptor de Transferrina
K1 Transferrin receptor
K1 Elastina
K1 Elastin
AB The development of mucoadhesive materials is of great interest and is also a major challenge. Being adsorption sites, mucosae are suitable targets for drug delivery, but as defensive barriers they are complex biological surfaces to interact with, mainly due to their protective mucus layer. As such, first- and second-generation mucoadhesives focused on material-mucus interactions, whereas the third generation of mucoadhesives introduced structural motifs that are able to interact with the cells beneath the mucus layer. The combination of different prerequisites (water solubility, soft gel formation at body temperature and able to interact with the mucus) in a single molecule is easily achieved using elastin-like recombinamers (ELRs) given their multiple block design. Moreover, we have been able to introduce a short amino-acid sequence known as T7 that is able to bind to transferrin receptors in the epithelial cell layer. The T7 sequence enhances the cell-binding properties of the mucoadhesive ELR (MELR), as demonstrated using a Caco-2 epithelial cell model. In vivo experiments confirmed the mucoadhesive properties found in vitro.
PB Elsevier
SN 1742-7061
YR 2019
FD 2019
LK http://uvadoc.uva.es/handle/10324/35317
UL http://uvadoc.uva.es/handle/10324/35317
LA eng
NO Acta Biomaterialia, 2019,  Volume 88, Pages 241-250
NO Producción Científica
DS UVaDOC
RD 24-abr-2024