RT info:eu-repo/semantics/article
T1 Genetically Engineered Elastin-based Biomaterials for Biomedical Applications
A1 Santos García, María Mercedes
A1 Serrano Dúcar, Sofía
A1 González Valdivieso, Juan
A1 Vallejo Vicente, Reinaldo
A1 Girotti, Alessandra
A1 Cuadrado Curto, María Purificación
A1 Arias Vallejo, Francisco Javier
K1 Biomateriales
K1 Biomaterials
K1 Elastina
K1 Elastin
K1 Ingeniería genética
K1 Genetic engineering
K1 Aplicaciones biomédicas
K1 Biomedical Applications
AB Protein-based polymers are some of the most promising candidates for a new generation of innovative biomaterials as recent advances in genetic-engineering and biotechnological techniques mean that protein-based biomaterials can be designed and constructed with a high degree of complexity and accuracy. Moreover, their sequences, which are derived from structural protein-based modules, can easily be modified to include bioactive motifs that improve their functions and material-host interactions, thereby satisfying fundamental biological requirements.The accuracy with which these advanced polypeptides can be produced, and their versatility, self-assembly behavior, stimuli-responsiveness and biocompatibility, means that they have attracted increasing attention for use in biomedical applications such as cell culture, tissue engineering, protein purification, surface engineering and controlled drug delivery.The biopolymers discussed in this review are elastin-derived protein-based polymers which are biologically inspired and biomimetic materials. This review will also focus on the design, synthesis and characterization of these genetically encoded polymers and their potential utility for controlled drug and gene delivery, as well as in tissue engineering and regenerative medicine.
PB Benthan Science
SN 0929-8673
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/35328
UL http://uvadoc.uva.es/handle/10324/35328
LA eng
NO Current Medicinal Chemistry, 2018. 25 p.
NO Producción Científica
DS UVaDOC
RD 27-dic-2024