RT info:eu-repo/semantics/article
T1 A novel information criterion to elucidate a drug delivery mechanism from poly (acrylamide-co-2-hydroxyethyl methacrylate) reinforced with hydroxyapatite composite
A1 García Couce, Jomarien
A1 Campos, Yaima
A1 Torres, Susana
A1 Peón, Eduardo
A1 Fuentes, Gastón
A1 Almirall, Amisel
A1 Delgado, José Ángel
A1 Rodríguez Cabello, José Carlos
A1 Cruz Ricondo, Luis J.
K1 Criterio de información
K1 Information criterion
K1 Administración de medicamentos
K1 Drug delivery
K1 Poliacrilamida
K1 Polyacrylamide
AB Hydrophilic composites of poly (acrylamide-co-2-hydroxyethyl methacrylate) reinforced withhydroxyapatite were synthesized, characterized and evaluated as drug delivery systems. The results show a strong dependence of the polymer composition, the degree of crosslinking and the homogeneity of the particles dispersion (filler or the mixed drug) in the characteristics that were analyzed. The mechanical properties were better while the swelling and the diffusion coefficient were worse than hydrogels with cefazolin of similar compositions. Additionally, a new information criterionwas used to elucidate the best fit. The drug diffusion into the medium was anomalous with a tendency towards Case II transport, indicating that under certain conditions zero-order diffusion could be achieved. This fact suggests that these materials could be used in the manufacture of medical devices for the controlled delivery of drugs and active or biological principles, significantly improving therapeutic procedures today.
PB Elsevier
SN 0032-3861
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/35329
UL http://uvadoc.uva.es/handle/10324/35329
LA eng
NO Polymer, 2018, vol. 158. p. 279-288
NO Producción Científica
DS UVaDOC
RD 21-dic-2024