RT info:eu-repo/semantics/article
T1 Silk-ELR co-recombinamer covered stents obtained by electrospinning
A1 Putzu, M.
A1 Causa, F.
A1 Parente, Manuel
A1 González de Torre, Israel
A1 Rodríguez Cabello, José Carlos
A1 Netti, P.A.
K1 Elastin-like recombinamers
K1 Recombinantes tipo elastina
K1 Tissue engineering
K1 Ingeniería de tejidos
K1 Electrospinning
K1 Electrohilado
AB In the field of tissue engineering the choice of materials is of great importance given the possibilityto use biocompatible polymers produced by means of biotechnology. A large number of syntheticand natural materials have been used to this purpose and processed into scaffolds usingElectrospinning technique. Among materials that could be used for the fabrication of scaffold anddegradable membranes, natural polymers such as collagen, elastin or fibroin offer the possibilityto design structures strictly similar to the extracellular matrix (ECM). Biotechnology and genetic engineeringmade possible the advent of a new class of biopolymers called protein-based polymers.One example is represented by the silk-elastin-proteins that combine the elasticity and resilience ofelastin with the high tensile strength of silk-fibroin and display engineered bioactive sequences. Inthis work, we use electrospinning technique to produce a fibrous scaffold made of the corecombinamerSilk-ELR. Obtained fibres have been characterized from the morphological point ofview. Homogeneity and morphology have been explored using Scanning Electron Microscopy. Athorough study regarding the influence of Voltage, flow rate and distance have been carried out todetermine the appropriate parameters to obtain the fibrous mats without defects and with a gooddistribution of diameters. Cytocompatibility has also been in vitro tested. For the first time we usethe co-recombinamer Silk-ELR for the fabrication of a 2.5 angioplasty balloon coating. This structurecould be useful as a coated scaffold for the regeneration of intima layer of vessels.
PB Oxford University Press
SN 2056-3426
YR 2019
FD 2019
LK http://uvadoc.uva.es/handle/10324/36431
UL http://uvadoc.uva.es/handle/10324/36431
LA eng
NO Regenerative Biomaterials, 2019, vol. 6, n. 1. p. 21–28
NO Producción Científica
DS UVaDOC
RD 24-nov-2024