RT info:eu-repo/semantics/article
T1 Synthesis of Enantiopure Oxygen- and Nitrogen-Containing Heterocycles by Diastereoselective Ring-Closing Metathesis Reaction in Perhydro-1,3-benzoxazine Derivatives
A1 Gutiérrez Loriente, Agustín
A1 Martín Álvarez, José Miguel
A1 Prieto, Elena
A1 Andrés Juan, Celia
A1 Nieto Román, Francisco Javier
K1 Síntesis asimétrica
K1 Metátesis
K1 Asymmetric synthesis
K1 Metathesis
AB Diastereoselective ring‐closing metathesis reactions on chiral trienic perhydro‐1,3‐benzoxazines derived from (−)‐8‐aminomenthol featuring two diastereotopic olefin chains is described. The diastereochemical outcome of the cyclization appeared to be dependent on the length and position of the olefin chains in perhydro‐1,3‐benzoxazine, the degree of substitution of the double bonds and the ruthenium catalyst used. After separation of the diastereomers, and removal of the chiral auxiliary, enantiopure oxygen‐ and nitrogen‐containing heterocycles were obtained.
PB Wiley
SN 1615-4150
YR 2019
FD 2019
LK http://uvadoc.uva.es/handle/10324/38103
UL http://uvadoc.uva.es/handle/10324/38103
LA eng
NO Advanced Synthesis and Catalysis, Volume361, Issue 5, 2019  Pages 1042-1063
NO Producción Científica
DS UVaDOC
RD 23-nov-2024