RT info:eu-repo/semantics/article
T1 Chiral Bifunctional Thiosquaramides as Organocatalysts in the Synthesis of Enantioenriched 3,3-Disubstituted Oxindoles
A1 Rodríguez Ferrer, Patricia
A1 Naharro, Daniel
A1 Maestro Fernández, Alicia
A1 Andrés García, José María
A1 Pedrosa Sáez, Rafael
K1 Química orgánica
AB Four novel chiral bifunctional thiosquaramides have been prepared from cyclopentyl dithiosquarates and diamines derived from natural l‐Valine and l‐tert‐Leucine. The novel thiosquaramides have been tested as organocatalyst in the nitro‐Michael addition of 3‐substituted oxindoles to different β‐aryl‐substituted nitroalkenes. The reaction occurred easily in high yields and excellent stereoselectivities, showing that the novel organocatalysts are much more effective than their thioureas and squaramides homologs.
PB Willey
SN 1434-193X
YR 2019
FD 2019
LK http://uvadoc.uva.es/handle/10324/38452
UL http://uvadoc.uva.es/handle/10324/38452
LA eng
NO European Journal of Organic Chemistry 2019, 6539–6549
NO Producción Científica
DS UVaDOC
RD 24-nov-2024