RT info:eu-repo/semantics/doctoralThesis
T1 Biologically relevant subgroups within the schizophrenia syndrome
A1 Lubeiro Juárez, Alba
A2 Universidad de Valladolid. Instituto de Biología y Genética Molecular (IBGM)
K1 Schizophrenia
K1 Esquizofrenia
K1 2490 Neurociencias
K1 2490.01 Neurofisiología
K1 3211 Psiquiatría
K1 2409 Genética
AB In the present thesis, we aimed to explore the existence of biological subgroups within schizophrenia patients by using data from structural and functional brain connectivity as well as a genetic information. It includes five articles with sample sizes from 27 to 121 schizophrenia patients and 27 to 144 healthy controls. All patients were diagnosed according to DSM-IV or V criteria and their symptoms were scored using the Positive and Negative Syndrome Scale (PANSS). Structural connectivity was assessed in two different ways. Firstly, using structural magnetic resonance imaging (MRI) we extracted measures of cortical curvature. Secondly, diffusion magnetic resonance imaging (dMRI)  was used to obtain values of streamline count and fractional anisotropy in white matter tracts connecting a priori selected regions. Functional connectivity was calculated using electroencephalography (EEG) recordings during the performance of an auditive odd-ball task, in which participants were instructed to respond to infrequent targets while ignoring other stimuli. Then, small-worldness (SWn) index, which quantifies the efficiency of the global electrical network, was calculated at two temporal windows: before and after the target stimulus onset (baseline/pre-stimulus and response window, respectively). We focused our study on the SWn difference between pre-stimulus and response windows as a measure of modulation efficiency.
YR 2019
FD 2019
LK http://uvadoc.uva.es/handle/10324/39211
UL http://uvadoc.uva.es/handle/10324/39211
LA eng
NO Departamento de Pediatría e Inmunología, Obstetricia y Ginecología, Nutrición y Bromatología, Psiquiatría e Historia de la Ciencia
DS UVaDOC
RD 30-abr-2024