RT info:eu-repo/semantics/article
T1 Effects of Zinc supplementation on nutritional status in children with chronic kidney disease: A randomized trial
A1 Escobedo Monge, Marlene Fabiola
A1 Ayala Macedo, Guido
A1 Shakihara, Graciela
A1 Peralta, Silvia
A1 Almaraz Gómez, Ana
A1 Barrado Esteban, Enrique
A1 Marugán de Miguelsanz, José Manuel
K1 Zinc
K1 Hypozincemia
K1 Kidney - Diseases
AB Zinc is an essential micronutrient for human beings and its deficiencya ects their normal growth and development. Objective: The main aim was to evaluate thee ect of two doses of zinc supplementation (ZS) on the nutritional status in chronic kidneydisease (CKD) children. Methods: A randomized-trial multicentric study was conducted in 48CKD (23 females) patients under 18-years-old, for a year. At random, participants took 30 or15 mg/day of ZS, respectively. Anthropometric measurements and biochemical analysis wereperformed. Hypozincemia was determined by serum zinc concentration (SZC) using atomicabsorption spectrophotometry. The positive or negative change in patients’ body mass index (BMI)Z-score, serum albumin, zinc and C-reactive protein (CRP) levels were used to evaluate the e ectof ZS. Results: Mean SZC was normal before and after ZS. Despite ZS, there were no significantchanges in serum albumin, zinc and CRP levels. A positive and significant association was observedbetween SZC and serum albumin before (p = 0.000) and after (p = 0.007) ZS. In both groups of ZS,there was a small but positive and significant change in body mass and normalization in BMI Z-score,hypoalbuminemia, hypozincemia and high CRP, especially with 30 mg/day of ZS. Conclusions: Zincsupplementation may be beneficial for nutritional status in children and adolescents with CKD
PB MDPI
YR 2019
FD 2019
LK http://uvadoc.uva.es/handle/10324/39902
UL http://uvadoc.uva.es/handle/10324/39902
LA eng
NO NUTRIENTS, 2019, vol.11, n. 11, p.  2671
DS UVaDOC
RD 14-oct-2024