RT info:eu-repo/semantics/article
T1 Copper complexes for the promotion of iminopyridine ligands derived from β-alanine and self-aldol additions: relaxivity and cytotoxic properties
A1 Álvarez Miguel, Lucía
A1 Álvarez Miguel, Inés
A1 Martín Álvarez, José Miguel
A1 Álvarez González, Celedonio Manuel
A1 Rogez, Guillaume
A1 García Rodríguez, Raúl
A1 Miguel San José, Daniel
K1 Copper complexes
K1 Complejos de cobre
K1 Relaxivity
K1 Relajabilidad
K1 Cytotoxicity
K1 Citotoxicidad
K1 2303.18 Metales
K1 2303.29 Elementos de Transición
AB In the study presented herein, we explore the ability of copper complexes with coordinated pyridine-2-carboxaldehyde (pyca) or 2-acetylpyridine (acepy) ligands to promote the addition of amines (Schiff condensation) and other nucleophiles such as alcohols (hemiacetal formation). Distinct reactivity patterns are observed: unlike pyca complexes, acepy copper complexes can promote self-aldol addition. The introduction of a flexible chain via Schiff condensation with β-alanine allows the possibility of chelate ring ring-opening processes mediated by pH. Further derivatization of the complex [CuCl(py-2-C(H)[double bond, length as m-dash]NCH2CH2COO)] is possible by replacing its chloride ligand with different pseudohalogens (N3−, NCO− and NCS−). In addition to the change in their magnetism, which correlates with their solid-state structures, more unexpected effects in their cytotoxicity and relaxitivities are observed, which determines their possibility to be used as MRI contrast agents. The replacement of a chloride by another pseudohalogen, although a simple strategy, can be used to critically change the cytotoxicity of the Schiff base copper (II) complex and its selectivity towards specific cell lines.
PB Royal Society of Chemistry
SN 1477-9234
YR 2019
FD 2019
LK http://uvadoc.uva.es/handle/10324/39915
UL http://uvadoc.uva.es/handle/10324/39915
LA eng
NO Dalton Transactions, 2019, n. 48, p. 17544-17555
NO Producción Científica
DS UVaDOC
RD 17-jul-2024