RT info:eu-repo/semantics/article
T1 Trends in the design and use of elastin-like recombinamers as biomaterials
A1 Ibáñez Fonseca, Arturo
A1 Flora, Tatjana
A1 Acosta Rodríguez, Sergio
A1 Rodríguez Cabello, José Carlos
K1 Biomaterials
K1 Biomateriales
K1 Elastin-like recombinamers
K1 Recombinantes tipo elastina
K1 Intrinsically disordered proteins
K1 Proteínas intrínsecamente desestructuradas
K1 Drug delivery
K1 Administración de medicamentos
K1 Tissue engineering
K1 Ingeniería de tejidos
AB Elastin-like recombinamers (ELRs), which derive from one of the repetitive domains found in natural elastin, have been intensively studied in the last few years from several points of view. In this mini review, we discuss all the recent works related to the investigation of ELRs, starting with those that define these polypeptides as model intrinsically disordered proteins or regions (IDPs or IDRs) and its relevance for some biomedical applications. Furthermore, we summarize the current knowledge on the development of drug, vaccine and gene delivery systems based on ELRs, while also emphasizing the use of ELR-based hydrogels in tissue engineering and regenerative medicine (TERM). Finally, we show different studies that explore applications in other fields, and several examples that describe biomaterial blends in which ELRs have a key role. This review aims to give an overview of the recent advances regarding ELRs and to encourage further investigation of their properties and applications.
PB Elsevier
SN 0945-053X
YR 2019
FD 2019
LK http://uvadoc.uva.es/handle/10324/40373
UL http://uvadoc.uva.es/handle/10324/40373
LA eng
NO Matrix Biology, 2019, vol. 84. p. 111-126
NO Producción Científica
DS UVaDOC
RD 22-nov-2024