RT info:eu-repo/semantics/article
T1 Ebulin from dwarf elder (Sambucus ebulus L.): A mini-review
A1 Jiménez López, María del Pilar
A1 Tejero del Río, Jesús
A1 Córdoba Diaz, Damián
A1 Quinto Fernández, Emiliano José
A1 Garrosa García, Manuel
A1 Gayoso Rodríguez, Manuel José
A1 Girbés Juan, Tomás
K1 Dwarf Elder
K1 Saúco menor
K1 Lectin
K1 Lectina
K1 Ebulin
K1 Ebulina
K1 Ricin
K1 Ricina
AB Sambucus ebulus L. (dwarf elder) is a medicinal plant, the usefulness of which also as food is restricted due to its toxicity. In the last few years, both the chemistry and pharmacology of Sambucus ebulus L. have been investigated. Among the structural and functional proteins present in the plant, sugar-binding proteins (lectins) with or without anti-ribosomal activity and single chain ribosome-inactivating proteins (RIPs) have been isolated. RIPs are enzymes (E.C. 3.2.2.22) that display N-glycosidase activity on the 28S rRNA subunit, leading to the inhibition of protein synthesis by arresting the step of polypeptide chain elongation. The biological role of all these proteins is as yet unknown. The evidence suggests that they could be involved in the defense of the plant against predators and viruses or/and a nitrogen store, with an impact on the nutritional characteristics and food safety. In this mini-review we describe all the isoforms of ebulin that have to date been isolated from dwarf elder, as well as their functional characteristics and potential uses, whilst highlighting concern regarding ebulin toxicity.
PB MDPI
SN 2072-6651
YR 2015
FD 2015
LK http://uvadoc.uva.es/handle/10324/40990
UL http://uvadoc.uva.es/handle/10324/40990
LA eng
NO Toxins, 2015, vol. 7, n. 3. p. 648-658
NO Producción Científica
DS UVaDOC
RD 24-nov-2024