RT info:eu-repo/semantics/article
T1 Toxicity of the anti-ribosomal lectin ebulin f in lungs and intestines in elderly mice
A1 Garrosa García, Manuel
A1 Jiménez López, María del Pilar
A1 Tejero del Río, Jesús
A1 Cabrero Lobato, Patricia
A1 Córdoba Diaz, Damián
A1 Quinto Fernández, Emiliano José
A1 Gayoso Rodríguez, Manuel José
A1 Girbés Juan, Tomás
K1 Dwarf Elder
K1 Saúco menor
K1 Ebulin f
K1 Ebulina f
K1 Ribosome-inactivating proteins
K1 Proteínas inactivadoras de ribosomas
K1 3214 Toxicología
AB All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in six-week-old mice, where it was found that the intestines were primary targets for it when administered intraperitoneally (i.p.). We performed experiments to assess whether ebulin f administration to six- and 12-month-old mice would trigger higher toxicity than that displayed in six-week-old mice. In the present report, we present evidence indicating that the toxicological effects of ebulin f after its i.p. administration to elderly mice are exerted on the lungs and intestines by an increased rate of apoptosis. We hypothesize that the ebulin f apoptosis-promoting action together with the age-dependent high rate of apoptosis result in an increase in the lectin’s toxicity, leading to a higher lethality level.
PB MDPI
SN 2072-6651
YR 2015
FD 2015
LK http://uvadoc.uva.es/handle/10324/40991
UL http://uvadoc.uva.es/handle/10324/40991
LA eng
NO Toxins, 2015, vol. 7, n. 2. p. 367-379
NO Producción Científica
DS UVaDOC
RD 22-nov-2024