RT info:eu-repo/semantics/article
T1 Elderberries: A source of ribosome-inactivating proteins with lectin activity
A1 Tejero del Río, Jesús
A1 Jiménez López, María del Pilar
A1 Quinto Fernández, Emiliano José
A1 Córdoba Diaz, Damián
A1 Garrosa García, Manuel
A1 Córdoba Diaz, Manuel
A1 Gayoso Rodríguez, Manuel José
A1 Girbés Juan, Tomás
K1 Dwarf elder
K1 Saúco menor
K1 Black elder
K1 Saúco negro
K1 Ebulin
K1 Ebulina
K1 Immunotoxins
K1 Inmunotoxinas
AB Sambucus (Adoxaceae) species have been used for both food and medicine purposes. Among these, Sambucus nigra L. (black elder), Sambucus ebulus L. (dwarf elder), and Sambucus sieboldiana L. are the most relevant species studied. Their use has been somewhat restricted due to the presence of bioactive proteins or/and low molecular weight compounds whose ingestion could trigger deleterious effects. Over the last few years, the chemical and pharmacological characteristics of Sambucus species have been investigated. Among the proteins present in Sambucus species both type 1, and type 2 ribosome-inactivating proteins (RIPs), and hololectins have been reported. The biological role played by these proteins remains unknown, although they are conjectured to be involved in defending plants against insect predators and viruses. These proteins might have an important impact on the nutritional characteristics and food safety of elderberries. Type 2 RIPs are able to interact with gut cells of insects and mammals triggering a number of specific and mostly unknown cell signals in the gut mucosa that could significantly affect animal physiology. In this paper, we describe all known RIPs that have been isolated to date from Sambucus species, and comment on their antiviral and entomotoxic effects, as well as their potential uses.
PB MDPI
SN 1420-3049
YR 2015
FD 2015
LK http://uvadoc.uva.es/handle/10324/40992
UL http://uvadoc.uva.es/handle/10324/40992
LA eng
NO Molecules, 2015, vol. 20, n. 2. p. 2364-2387
NO Producción Científica
DS UVaDOC
RD 25-nov-2024