RT info:eu-repo/semantics/article
T1 Use of ribosome-inactivating proteins from Sambucus for the construction of immunotoxins and conjugates for cancer therapy
A1 Ferreras Rodríguez, José Miguel
A1 Citores González, Lucía
A1 Iglesias Álvarez, María del Rosario
A1 Jiménez López, María del Pilar
A1 Girbés Juan, Tomás
K1 Elder tree
K1 Saúco
K1 Ribosome-inactivating proteins
K1 Proteínas inactivadoras de ribosomas
K1 Immunotoxins
K1 Inmunotoxinas
K1 Endoglin
K1 Endoglina
AB The type 2 ribosome-inactivating proteins (RIPs) isolated from some species belonging to the Sambucus genus, have the characteristic that although being even more active than ricin inhibiting protein synthesis in cell-free extracts, they lack the high toxicity of ricin and related type 2 RIPs to intact cells and animals. This is due to the fact that after internalization, they follow a different intracellular pathway that does not allow them to reach the cytosolic ribosomes. The lack of toxicity of type 2 RIPs from Sambucus make them good candidates as toxic moieties in the construction of immunotoxins and conjugates directed against specific targets. Up to now they have been conjugated with either transferrin or anti-CD105 to target either transferrin receptor- or endoglin-overexpressing cells, respectively.
PB MDPI
SN 2072-6651
YR 2011
FD 2011
LK http://uvadoc.uva.es/handle/10324/40994
UL http://uvadoc.uva.es/handle/10324/40994
LA eng
NO Toxins, 2011, vol. 3, n. 5. p. 420-441
NO Producción Científica
DS UVaDOC
RD 18-nov-2024