RT info:eu-repo/semantics/article
T1 Citokine, chemokine and immune activation pathway profiles in celiac disease : an immune system activity screening by expression macroarrays.
A1 Garrote Adrados, José Antonio
A1 Gómez, Emma
A1 León, Alberto José
A1 Bernardo Ordiz, David
A1 Calvo Romero, María del Carmen
A1 Fernández Salazar, Luis Ignacio
A1 Blanco Quirós, Alfredo
A1 Arranz Sanz, Eduardo
K1 Enfermedad celíaca
AB The aims of the study were to assess the usefulness of expression macroarrays to determine the pattern of expressionof cytokines, chemokines and molecules related to immune system activation pathways, in non-stimulated intact intestinaltissue specimens from patients with active CD (aCD) and on a gluten-free diet (GFD), to compare it with two groups ofcontrols with either normal or altered mucosal architecture, and to establish putative targets for diagnostic markers ortherapeutic intervention. We have experienced the lack of sensitivity to detect signal of genes with low level of expression.In spite of that, active CD seems to show a Th1 cytokine pattern, but with signs of Th2 activity. Cytokines such as IL-9,IL-11, IL-21 or MIF might be involved in mucosal infl ammation in CD. In GFD, some memory cells and DC’s activityremains, and factors that maintain this remnant activation might be responsible of the fast mucosal response on gluten challenge.STAT3 and STAT5 pathways, and their regulatory molecules SOCS’s may result keys for understanding mucosalinfl ammation in gut and putative targets for further research.
PB Instituto de Biología y Genética Molecular (IBGM)
SN 1177-3928
YR 2008
FD 2008
LK http://uvadoc.uva.es/handle/10324/4181
UL http://uvadoc.uva.es/handle/10324/4181
LA eng
NO Drug Target Insights, 3. p. 1-11
NO Producción Científica
DS UVaDOC
RD 11-jul-2024