RT info:eu-repo/semantics/article
T1 Tachyphylaxis to β2-agonists in Spanish asthmatic patients could be modulated by β2-adrenoceptor gene polymorphisms
A1 Tellería Orriols, Juan José
A1 Blanco Quirós, Alfredo
A1 Muntión, Sandra
A1 Garrote Adrados, José Antonio
A1 Arranz Sanz, Eduardo
A1 Armentia Medina, Alicia
A1 Díez, Ignacio
A1 Castro, Jesús
K1 Taquifilaxia
K1 Asma
K1 Alelos
K1 Polimorfismos
K1 medicina
AB The study of determinants of asthma is a subject of much interest currently, especially the pharmacogenetic aspects of asthma management. Genetic polymorphisms affecting amino-acids at positions 16 and 27 within β2-adrenoceptor (β2AR) gene have been implicated in the asthma phenotypes and influence on the variability observed in response to use of bronchodilator agents used in the treatment of asthma. Whether these polymorphisms alter the bronchoprotection response to -agonist treatment in Spanish asthmatic population is unknown. The aim of this study was to investigate whether genetic polymorphisms within β2AR gene modulate the clinical outcomes of the individual response to β2-agonist therapy and the development of desensitization in Spanish asthmatic patients.
PB Elsevier
SN 0954-6111
YR 2006
FD 2006
LK http://uvadoc.uva.es/handle/10324/42060
UL http://uvadoc.uva.es/handle/10324/42060
LA eng
NO Respiratory Medicine, 2006, Volume 100, n. 6, p.1072-1078
NO Producción Científica
DS UVaDOC
RD 18-nov-2024