RT info:eu-repo/semantics/article
T1 Dual Self-Assembled Nanostructures from Intrinsically Disordered Protein Polymers with LCST Behavior and Antimicrobial Peptides
A1 Acosta Rodríguez, Sergio
A1 Ye, Zhou
A1 Aparicio, Conrado
A1 Alonso Rodrigo, Matilde
A1 Rodríguez Cabello, José Carlos
AB Antimicrobial peptides (AMPs) have attracted great interest as they constitute one of themost promising alternatives against drug-resistant infections. Their amphipathic natureprovides them antimicrobial and immunomodulatory properties but also the ability to selfassemble into supramolecular nanostructures. Here, we propose their use as selfassembling domains to drive hierarchical organization of intrinsically disordered proteinpolymers (IDPPs). Using a modular approach, hybrid protein-engineered polymers wererecombinantly produced, thus combining designer AMPs and a thermoresponsive IDPP,an elastin-like recombinamer (ELR). We exploited the ability of these AMPs and ELRs toself-assemble to develop supramolecular nanomaterials by way of a dual-assemblyprocess. First, the AMPs trigger the formation of nanofibers, then thethermoresponsiveness of the ELRs enables assembly into fibrillar aggregates. Theinterplay between the assembly of AMPs and ELRs provides an innovative molecular toolin the development of self-assembling nanosystems with potential use forbiotechnological and biomedical applications.
PB American Chemical Society
SN 1525-7797
YR 2020
FD 2020
LK http://uvadoc.uva.es/handle/10324/42388
UL http://uvadoc.uva.es/handle/10324/42388
LA spa
NO Biomacromolecules 2020 (in press)
DS UVaDOC
RD 05-may-2024