RT info:eu-repo/semantics/article
T1 Experimental study of speciation and mechanistic implications when using chelating ligands in aryl-alkynyl Stille coupling
A1 Gallego Díaz, Ana María
A1 Peñas de Frutos, Marconi Nicolás
A1 Marcos Ayuso, Guillermo
A1 Martín Álvarez, José Miguel
A1 Martínez de Ilarduya Martínez de Ilarduya, Jesús María
A1 Espinet Rubio, Pablo
K1 palladium
AB Neutral palladium(II) complexes [Pd(Rf)X(P–L)] (Rf = 3,5-C6Cl2F3, X = Cl, I, OTf) with P–P (dppe and dppf) and P–N (PPh2(bzN)) ligands have chelated structures in the solid-state, except for P–L = dppf and X = Cl, were chelated and dimeric bridged structures are found. The species present in solution in different solvents (CDCl3, THF, NMP and HMPA) have been characterised by 19F and 31P{1H} NMR and conductivity studies. Some [Pd(Rf)X(P–L)] complexes are involved in equilibria with [Pd(Rf)(solv)(P–L)]X, depending on the solvent and X. The ΔH° and ΔS° values of these equilibria explain the variations of ionic vs. neutral complexes in the range 183–293 K. Overall the order of coordination strength of solvents and anionic ligands is: HMPA ≫ NMP > THF and I−, Cl− > TfO−. This coordination preference is determining the complexes participating in the alkynyl transmetalation from PhC[triple bond, length as m-dash]CSnBu3 to [Pd(Rf)X(P–L)] (X = OTf, I) in THF and subsequent coupling. Very different reaction rates and stability of intermediates are observed for similar complexes, revealing neglected complexities that catalytic cycles have to deal with. Rich information on the evolution of these Stille systems after transmetalation has been obtained that leads to proposal of a common behaviour for complexes with dppe and PPh2(bzN), but a different evolution for the complexes with dppf: this difference leads the latter to produce PhC[triple bond, length as m-dash]CRf and black Pd, whereas the two former yield PhC[triple bond, length as m-dash]CRf and [Pd(C[triple bond, length as m-dash]CPh)(SnBu3)(dppe)] or [Pd(C[triple bond, length as m-dash]CPh)(SnBu3){PPh2(bzN)}].
PB Royal Society of Chemistry
SN 1477-9226
YR 2020
FD 2020
LK http://uvadoc.uva.es/handle/10324/42666
UL http://uvadoc.uva.es/handle/10324/42666
LA eng
NO Dalton Transactions, 2020, 49, 11336-11345
NO Producción Científica
DS UVaDOC
RD 26-abr-2024