RT info:eu-repo/semantics/article
T1 Reactivity of Fluorinated-Chalcone Phosphines, RPEWO-F4, Induced by C–F Activation upon Coordination to PdCl2
A1 Peñas de Frutos, Marconi Nicolás
A1 Vélez Blasco, Andrea
A1 Espinet Rubio, Pablo
K1 Ephosphine
AB The E phosphine ligands (R = Ph, o-Tol, Cy), abbreviated as RPEWO-F4, are stable in solution, but they develop a rich reactivity on coordination to PdCl2. The chelate P-olefin coordination to PdCl2 leads eventually to a Z conformation of the fluorinated-chalcone group o-C6F4CH═CHC(O)Ph. From there, a cyclization reaction occurs involving the C═O group and activation of a F atom, yielding a strongly chelated PdCl2(P-carbene) complex. The carbene carbon atom in the complex displays some electrophilicity, which is expressed in hydrolysis, ammonolysis, and oxidation (with peroxide) reactions, affording PdCl2 complexes with new P,C,O-pincer, P,C,N-pincer, or P,O-chelate fluorinated ligands. The C–F activation reactions are slow in comparison to the catalysis rates when the [PdCl2(RPEWO-F4)] complexes have been used in Negishi catalyses. Consequently, the reactivity discussed here is not expected to interfere with the interpretation of the data obtained in Pd-catalytic studies or processes, at least for fast transmetalating nucleophiles.
PB American Chemical Society
SN 0276-7333
YR 2020
FD 2020
LK http://uvadoc.uva.es/handle/10324/42667
UL http://uvadoc.uva.es/handle/10324/42667
LA eng
NO Organometallics 2020, 39, 6, 841–847
NO Producción Científica
DS UVaDOC
RD 24-nov-2024