RT info:eu-repo/semantics/article
T1 Supercritical rosemary extracts, their antioxidant activity and effect on hepatic tumor progression
A1 Vicente, Gonzalo
A1 Molina, Susana
A1 González-Vallinas Garrachón, Margarita
A1 García Risco, Mónica R.
A1 Fornari, Tiziana
A1 Reglero, Guillermo
A1 Ramírez de Molina, Ana
K1 Cáncer de hígado
K1 Romero
K1 3207.13 Oncología
AB The use of supercritical fluid technology as an innovative technology to extract bioactive compounds has grown considerably in recent decades. Particularly, the recovery of antioxidants from different herbs is a matter of continuous research and development. Antioxidants can protect cells against the effects of free radicals and thus, play an important role in heart illness, cancer and other diseases.Rosemary (Rosmarinus officinalis L.) has been recognized as one of the Lamiaceae plant with many important biological activities. Particularly, large antioxidant power has been recognized in rosemary and main substances related with this activity were the phenolic diterpenes such as carnosol, rosmanol, carnosic acid, methyl carnosate, and phenolic acids such as the rosmarinic and caffeic acids. Moreover, carnosic acid and carnosol are recognized as the most abundant antioxidants present in rosemary.In this work, supercritical fluid technology was applied to produce rosemary extracts with different compositions and thus, with different bioactivity properties. Selected extracts, from the variety of samples obtained, were used to study the capability of rosemary supercritical extracts to inhibit the proliferation of human liver carcinoma cells. These extracts showed a dose-dependent effect on inhibiting the proliferation of human hepatoma cells. Moreover, observed citostaticity appeared to be significantly influenced by their different composition, suggesting a relevant role of the technology to produce the extracts and the consequently obtained compositions on the potential antitumoral activity of rosemary.
PB Elsevier
SN 0896-8446
YR 2013
FD 2013
LK http://uvadoc.uva.es/handle/10324/42705
UL http://uvadoc.uva.es/handle/10324/42705
LA eng
NO The Journal of Supercritical Fluids, 2013, vol. 79, p. 101-108
NO Producción Científica
DS UVaDOC
RD 27-jun-2024