RT info:eu-repo/semantics/article
T1 Investigating the role of the experimental protocol in phenylhydrazine-induced anemia on mice recovery
A1 Gandrillon, O.
A1 Crauste, F.
A1 Angulo Torga, Óscar
K1 Erythropoiesis model
K1 Experimental protocol modeling
K1 Nonlinear age-structured system
AB Production of red blood cells involves growth-factor mediated regulation of erythroid progenitor apoptosis and self-renewal. During severe anemia, characterized by a strong fall of the hematocrit followed by a recovery phase, these controls allow a fast recovery of the hematocrit and survival of the organism. Using a mathematical model of stress erythropoiesis and an ad hoc numerical method, we investigate the respective roles of anemia-inducing phenylhydrazine injections and physiological regulation on the organism’s recovery. By explicitly modeling the experimental protocol, we show that it mostly characterizes the fall of the hematocrit following the anemia and its severeness, while physiological process regulation mainly controls the recovery. We confront our model and our conclusions to similar experiments inducing anemia and show the model’s ability to reproduce several protocols of phenylhydrazine-induced anemia. In particular, we establish a link between phenylhydrazine effect and the severeness of the anemia.
PB Elsevier
SN 0022-5193
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/42956
UL http://uvadoc.uva.es/handle/10324/42956
LA spa
NO Journal of Theoretical Biology, January 2018, vol. 437, n. 21. p. 286–298
NO Producción Científica
DS UVaDOC
RD 23-dic-2024