RT info:eu-repo/semantics/article
T1 Controlled Production of Elastin-like Recombinamer Polymer-Based Membranes at a Liquid–Liquid Interface by Click Chemistry
A1 González Pérez, Miguel
A1 González de Torre, Israel
A1 Alonso Rodrigo, Matilde
A1 Rodríguez Cabello, José Carlos
AB Diffusion of organic and inorganic moleculescontrols most industrial and biological processes that occur in aliquid phase. Although significant efforts have been devoted to thedesign and operation of large-scale purification systems, diffusiondevices with adjustable biochemical characteristics have remaineddifficult to achieve. In this regard, micrometer-scale, bioinspiredmembranes with tunable diffusion properties have been engineeredby covalent cross-linking of two elastin-like recombinamers (ELRs)at a liquid−liquid interface. The covalent approach selectedprovides the desired ELR-based membranes with structuralsupport, and modulation of the concentration of the polypeptidesemployed confers direct control of the thickness, pore size, anddiffusive properties over a broad range of molecular weights (4−150 kDa). The recombinant and versatile nature of theproteinaceous building blocks employed further paves the way to engineering bioactive motifs within the membrane scaffold, therebywidening their applicability in the biological field.
PB ACS Publications
SN 1525-7797
YR 2020
FD 2020
LK http://uvadoc.uva.es/handle/10324/43328
UL http://uvadoc.uva.es/handle/10324/43328
LA spa
NO Biomacromolecules 2020, 21, 4149−4158
NO Producción Científica
DS UVaDOC
RD 14-oct-2024