RT info:eu-repo/semantics/doctoralThesis
T1 Use of Kv1.3 channel blockers for the prevention of restenosis in human vessels: Mechanisms and outcomes in diabetic patients
A1 Arévalo Martínez, Marycarmen
A2 Universidad de Valladolid. Facultad de Medicina
K1 Kv1.5
K1 Kv1.3
K1 Diabetes
K1 32 Ciencias Médicas
AB Vascular smooth muscle cells (VSMCs) can undergo phenotypicmodulation (PM) to a dedifferentiated state, which contributes toangiogenesis and vessel repair. PM is triggered by vascular surgeries suchas those directed to unclog obstructed vessels. However, an excessiveVSMC migration and proliferation drives intimal hyperplasia (IH) leading torestenosis. This situation is even worse in patients with backgrounddiseases like type 2 diabetes mellitus (T2DM). T2DM patients have moreaggressive forms of vascular disease and worse outcomes, withexacerbated restenosis after vascular surgery.We have previously demonstrated that an increased functional expressionof the potassium channel Kv1.3 contributes to PM in several models ofVSMCs, as Kv1.3 blockers inhibit VSMCs migration and proliferation. Inaddition, we found that Kv1.3 increased activity upon PM is a consequenceof Kv1.5 downregulation, so that the changes in Kv1.3 to Kv1.5 ratio candefine VSMCs phenotype.
YR 2020
FD 2020
LK http://uvadoc.uva.es/handle/10324/43490
UL http://uvadoc.uva.es/handle/10324/43490
LA eng
NO Departamento de Bioquímica y Biología Molecular y Fisiología
DS UVaDOC
RD 12-nov-2024