RT info:eu-repo/semantics/article
T1 Bifunctional thiourea-modified polymers of intrinsic microporosity for enantioselective α-amination of 3-aryl-2-oxindoles in batch and flow conditions
A1 Martín Maroto, Laura
A1 Maestro Fernández, Alicia
A1 Andrés García, José María
A1 Pedrosa Sáez, Rafael
K1 Polímeros
K1 Polymers
K1 2306 Química Orgánica
AB Two novel polymers of intrinsic microporosity decorated with chiral thioureas have been used as recoverable organocatalysts in enantioselective α-amination of 3-aryl-substituted oxindoles, creating a quaternary stereocenter. Both catalysts were able to promote the reaction in excellent yields and good enantioselection. Catalyst II, with a pyridyl nucleus, was used in recycling experiments maintaining the activity without additional reactivation, and in flow processes allowing the synthesis of the amination product in multigram scale.
PB Royal Society of Chemistry
SN 1477-0520
YR 2020
FD 2020
LK http://uvadoc.uva.es/handle/10324/43682
UL http://uvadoc.uva.es/handle/10324/43682
LA eng
NO Organic and Biomolecular Chemistry, 2020, 18, 9275-9283
NO Producción Científica
DS UVaDOC
RD 19-abr-2024