RT info:eu-repo/semantics/article
T1 Copper and Copper/Zinc ratio in a series of cystic fibrosis patients
A1 Escobedo Monge, Marlene Fabiola
A1 Barrado Esteban, Enrique
A1 Alonso Vicente, Carmen
A1 Escobedo Monge, María Antonieta
A1 Torres Hinojal, María Carmen
A1 Marugán de Miguelsanz, José Manuel
A1 Redondo del Río, María Paz
K1 hypocupremia; hypercupremia; inflammatory response; risk of zinc deficiency; serum copper/zinc ratio
K1 3201.10 Pediatría
AB t: Cystic fibrosis (CF) patients require a stable and sufficient supply of micronutrients. Since copper is an essential micronutrient for human development, a cross-sectional study was carried out to investigate the serum copper levels, serum copper/zinc (Cu/Zn) ratios, and their relationship with nutritional indicators in a group of CF patients. Anthropometric, biochemical, and dietary measurements, an abdominal ultrasound, and respiratory and pancreatic tests were conducted. Seventeen CF patients were studied (10 females, 59%), 76.5% of whom were ∆F580. Their mean serum copper (113 ± 23 µg/dL) was normal, and there was only one teenager with hypocupremia (6%) and two children with hypercupremia (18%). A significant association between serum copper and zinc levels was discovered. The Cu/Zn ratio was higher than 1.00 for 94% of patients, which is an indicator of an inflammation status. There was no significant correlation between the serum copper concentrations and respiratory and pancreatic function, respiratory colonization, and the results of the abdominal ultrasound. Linear regression analysis showed that serum copper had a positive association with both the Z-score body mass index (BMI) and mean bone conduction speed (BCS). Therefore, since 94% of CF patients had a Cu/Zn ratio > 1.00, this factor must alert us to consider the risk of zinc deficiency and high inflammatory response. The measurement of serum zinc alone does not show one’s zinc status. However, the Cu/Zn ratio may be an indicator of zinc deficiency and the inflammatory status of CF patients.
PB MDPI
YR 2020
FD 2020
LK http://uvadoc.uva.es/handle/10324/43806
UL http://uvadoc.uva.es/handle/10324/43806
LA eng
NO Nutrients 2020, vol. 12, n. 11, 3344
DS UVaDOC
RD 27-abr-2024