RT info:eu-repo/semantics/article
T1 COVID-19 comes 40 years after AIDS - any lesson?
A1 Soriano, Vicente
A1 Barreiro, Pablo
A1 Ramos, José Manuel
A1 Eiros Bouza, José María
A1 Mendoza, Carmen de
K1 COVID-19
K1 SIDA
K1 2420 Virología
AB The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has hit health-care systems and societies in an unprecedented manner. In 1981, the first cases of AIDS were reported and wide diagnostic testing helped to characterize high-risk groups and the global burden of the epidemic. With Coronavirus Disease (COVID)-19, everything has happened too fast and both cases and fatalities are huge but still uncertain in most places. Diagnostic testing of active and past SARS-CoV-2 infections needs to expand rapidly, ideally using rapid tests. COVID-19 deaths are highly concentrated in the elderly population, with a large proportion of fatalities being "with" rather than "by" SARS-CoV-2 infection. They are often the result of inadequate health care due to overwhelming demands. To date, there is no specific therapy for SARS-CoV-2 infection. Several antivirals are being tested clinically, including remdesivir, at this time the most promising. For others such as lopinavir/ritonavir, neither significant virological nor clinical benefit has been shown. Given the characteristic pulmonary cytokine storm underlying the pathogenic mechanism of severe COVID-19 pneumonia and acute respiratory distress, antiinflammatory agents are being investigated. The benefit of orticosteroids, hydroxychloroquine, etc., is limited. Monoclonal antibodies targeting different pro-inflammatory cytokines, such as tocilizumab, an anti-interleukin 6 agent, are being tried with encouraging results. Ultimately a protective vaccine will be the best response for controlling the COVID-19 pandemic.
PB Permanyer
SN 1139-6121
YR 2020
FD 2020
LK http://uvadoc.uva.es/handle/10324/44140
UL http://uvadoc.uva.es/handle/10324/44140
LA eng
NO AIDS Reviews, 2020, vol. 22, n.2, p. 63-77
NO Producción Científica
DS UVaDOC
RD 17-jul-2024