RT info:eu-repo/semantics/article
T1 Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: The REGICOR study
A1 Dégano, Irene R.
A1 Camps Vilaró, Anna
A1 Subirana, Isaac
A1 García Mateo, Nadia
A1 Cidad Velasco, María del Pilar
A1 Muñoz Aguayo, Daniel
A1 Puigdecanet, Eulàlia
A1 Nonell, Lara
A1 Vila, Joan
A1 Crepaldi, Felipe M.
A1 Gonzalo Calvo, David de
A1 Llorente Cortés, Vicenta
A1 Pérez García, María Teresa
A1 Elosua, Roberto
A1 Fitó, Montserrat
A1 Marrugat, Jaume
K1 Arterias coronarias - Enfermedades
K1 Lipoproteins
K1 Lipoproteínas
K1 MicroRNAs
K1 MicroARNs
K1 Myocardial infarction
K1 Infarto de miocardio
K1 3205.01 Cardiología
AB Risk prediction tools cannot identify most individuals at high coronary artery disease (CAD) risk. Oxidized low-density lipoproteins (oxLDLs) and microRNAs are actively involved in atherosclerosis. Our aim was to examine the association of CAD and oxLDLs-induced microRNAs, and to assess the microRNAs predictive capacity of future CAD events. Human endothelial and vascular smooth muscle cells were treated with oxidized/native low-density lipoproteins, and microRNA expression was analyzed. Differentially expressed and CAD-related miRNAs were examined in serum samples from (1) a case-control study with 476 myocardial infarction (MI) patients and 487 controls, and (2) a case-cohort study with 105 incident CAD cases and 455 randomly-selected cohort participants. MicroRNA expression was analyzed with custom OpenArray plates, log rank tests and Cox regression models. Twenty-one microRNAs, two previously undescribed (hsa-miR-193b-5p and hsa-miR-1229-5p), were up- or down-regulated upon cell treatment with oxLDLs. One of the 21, hsa-miR-122-5p, was also upregulated in MI cases (fold change = 4.85). Of the 28 CAD-related microRNAs tested, 11 were upregulated in MI cases-1 previously undescribed (hsa-miR-16-5p)-, and 1/11 was also associated with CAD incidence (adjusted hazard ratio = 0.55 (0.35–0.88)) and improved CAD risk reclassification, hsa-miR-143-3p. We identified 2 novel microRNAs modulated by oxLDLs in endothelial cells, 1 novel microRNA upregulated in AMI cases compared to controls, and one circulating microRNA that improved CAD risk classification.
PB MPDI
SN 2077-0383
YR 2020
FD 2020
LK http://uvadoc.uva.es/handle/10324/44469
UL http://uvadoc.uva.es/handle/10324/44469
LA eng
NO Journal of Clinical Medicine, 2020, vol. 9, n. 5. 14 p.
NO Producción Científica
DS UVaDOC
RD 18-nov-2024