RT info:eu-repo/semantics/article
T1 Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice
A1 Villa Pérez, Pablo
A1 Merino Antolín, Beatriz
A1 Fernández Díaz, Cristina María
A1 Cidad Velasco, María del Pilar
A1 Domínguez Lobatón, María Carmen
A1 Moreno Díaz-Calderón, Alfredo
A1 Muturi, Harrison T.
A1 Ghadieh, Hilda E.
A1 Leissring, Malcolm A.
A1 Cózar Castellano, Irene
A1 Perdomo Hernández, Germán
K1 Insulin-degrading enzymes
K1 Encimas degradadoras de insulina
K1 Insulin receptors
K1 Receptores de insulina
AB The role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood. OBJECTIVE: This study aimed to clarify whether IDE is a major mediator of insulin clearance, and to define its role in the etiology of hepatic insulin resistance.
PB Elsevier
SN 0026-0495
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/44474
UL http://uvadoc.uva.es/handle/10324/44474
LA eng
NO Metabolism, 2018, vol. 88. p. 1-11
NO Producción Científica
DS UVaDOC
RD 18-abr-2024