RT info:eu-repo/semantics/article
T1 Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization
A1 Alajbegovic, Azra
A1 Turczyńska, Karolina M.
A1 Thi Hien, Tran
A1 Cidad Velasco, María del Pilar
A1 Swärd, Karl
A1 Hellstrand, Per
A1 Della Corte, Alessandro
A1 Forte, Amalia
A1 Albinsson, Sebastian
K1 Cardiovascular diseases
K1 Enfermedades cardiovasculares
K1 Arterial smooth muscle
K1 Músculo liso vascular
K1 Phenotype
K1 Fenotipo
K1 Actin polymerization
K1 Polimerización de actina
K1 MicroRNA
K1 MicroARN
AB The dynamic properties of the actin cytoskeleton in smooth muscle cells play an important role in a number of cardiovascular disease states. The state of actin does not only mediate mechanical stability and contractile function but can also regulate gene expression via myocardin related transcription factors (MRTFs). These transcriptional co-activators regulate genes encoding contractile and cytoskeletal proteins in smooth muscle. Regulation of small non-coding microRNAs (miRNAs) by actin polymerization may mediate some of these effects. MiRNAs are short non-coding RNAs that modulate gene expression by post-transcriptional regulation of target messenger RNA. In this study we aimed to determine a profile of miRNAs that were 1) regulated by actin/MRTF-A, 2) associated with the contractile smooth muscle phenotype and 3) enriched in muscle cells.
PB Elsevier
SN 0167-4889
YR 2017
FD 2017
LK http://uvadoc.uva.es/handle/10324/44481
UL http://uvadoc.uva.es/handle/10324/44481
LA eng
NO Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017, vol. 1864, n. 6. p. 1088-1098
NO Producción Científica
DS UVaDOC
RD 18-nov-2024