RT info:eu-repo/semantics/article T1 Are Kv channels the essence of O2 sensing? A1 Pérez García, María Teresa A1 López López, José Ramón K1 Potassium channels K1 Canales de potasio K1 Oxygen sensing K1 Detección de oxígeno AB This report represents a relevant contribution to the study of oxygen sensing for two main reasons. First, it shows an approach adequate for identification of a putative O2-sensitive K+ channel, by moving from the modulation by hypoxia of a recombinant channel back to its physiological context, the role of this channel in the response to low Po2 of the native cells. Second, it demonstrates that hypoxic inhibition of the recombinant Kv3.1 channels is retained in excised membrane patches, pointing to a membrane-delimited mechanism as the origin of hypoxic responses. The importance of this latter finding deserves additional comment. PB American Heart Association SN 1524-4571 YR 2000 FD 2000 LK http://uvadoc.uva.es/handle/10324/44606 UL http://uvadoc.uva.es/handle/10324/44606 LA eng NO Circulation Research, 2000, vol. 86, n. 5. p. 490-491 NO Producción Científica DS UVaDOC RD 03-nov-2024