RT info:eu-repo/semantics/article
T1 Are Kv channels the essence of O2 sensing?
A1 Pérez García, María Teresa
A1 López López, José Ramón
K1 Potassium channels
K1 Canales de potasio
K1 Oxygen sensing
K1 Detección de oxígeno
AB This report represents a relevant contribution to the study of oxygen sensing for two main reasons. First, it shows an approach adequate for identification of a putative O2-sensitive K+ channel, by moving from the modulation by hypoxia of a recombinant channel back to its physiological context, the role of this channel in the response to low Po2 of the native cells. Second, it demonstrates that hypoxic inhibition of the recombinant Kv3.1 channels is retained in excised membrane patches, pointing to a membrane-delimited mechanism as the origin of hypoxic responses. The importance of this latter finding deserves additional comment.
PB American Heart Association
SN 1524-4571
YR 2000
FD 2000
LK http://uvadoc.uva.es/handle/10324/44606
UL http://uvadoc.uva.es/handle/10324/44606
LA eng
NO Circulation Research, 2000, vol. 86, n. 5. p. 490-491
NO Producción Científica
DS UVaDOC
RD 21-dic-2024