RT info:eu-repo/semantics/article
T1 Antibodies against 1940s era a/H1N1 influenza strains a/Weiss/43 and a/FM/1/47 and heterotypic responses after seasonal vaccination of an elderly Spanish population
A1 Sanz, Ivan
A1 Rojo, Silvia
A1 Tamames, Sonia
A1 Eiros Bouza, José María
A1 Ortiz de Lejarazu Leonardo, Raúl
K1 Anticuerpos
K1 Influenza
K1 32 Ciencias Médicas
AB Background and methodsElderly people have experienced several influenza natural infections and seasonal vaccinations during their lives. The aim of this work was to evaluate in an elderly Spanish population the presence of antibodies (Abs) against some 1940s era A/H1N1 influenza viruses and some new influenza viruses. We also evaluated the homologous and heterotypic responses after seasonal influenza vaccination. We collected pre- and post-vaccination serum samples from 174 elderly people (≥65 years) who were vaccinated with seasonal influenza vaccines during the 2006–2007, 2008–2009, 2009–2010, and 2010–2011 northern hemisphere influenza campaigns. The presence of Abs against the 1940s era A/Weiss/43 and A/FM/1/47 strains of the A/H1N1 influenza virus was evaluated by using hemagglutination inhibition assays.ResultsPre-vaccination Abs against the A/Weiss/43 and A/FM/1/47 strains were present at protective titres (≥1/40) in 43.7% and 20.1% of the study population respectively. Seasonal influenza vaccination induced heterotypic seroconversion against A/Weiss/43 in 16.1% of the individuals and against A/FM/1/47 in 13.2% of the individuals. The seroprotection rate for the study population after seasonal vaccination was 63.2% against A/Weiss/43 and 31.0% against A/FM/1/47. The heterotypic response did not satisfy the European Medicament Agency criteria for people aged ≥60 years.ConclusionsA moderate percentage of elderly people had Abs against the 1940s era A/Weiss/43 and A/FM/1/47 strains of the A/H1N1 influenza subtype. Seasonal influenza vaccination induced a low but significant heterotypic response against both 1940s era influenza strains, reaching a high seroprotection rate for the A/Weiss/43 strain. Seasonal influenza vaccination can increase, within certain limitations, the Abs titres against old influenza strains not included in the composition of the vaccine itself.
PB BMC
SN 1742-4933
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/45044
UL http://uvadoc.uva.es/handle/10324/45044
LA eng
NO Immunity & Ageing, 2018, vol.15, n. 1
NO Producción Científica
DS UVaDOC
RD 06-ago-2024