RT info:eu-repo/semantics/article
T1 Non-steroidal anti-inflammatory drugs (NSAIDs) and neuroprotection in the elderly: a view from the mitochondria
A1 Calvo Rodríguez, María
A1 Núñez Llorente, Lucía
A1 Villalobos Jorge, Carlos
K1 Aging
K1 Envejecimiento
K1 Neuroprotection
K1 Neuroprotección
K1 Mitochondria
K1 Mitocondrias
AB The most important risk factor for stroke and neurodegeneration isaging. In fact, survival after stroke diminishes largely with aging. Infact, recovery after brain artery occlusion is dramatically worsenedby aging, even normal aging is associated with neuron damage andcognitive decline. Mechanisms involved in aging-related, cognitivedecline and susceptibility to neuron damage in stroke and neurodegeneration are largely unknown. One of the most important mechanisms contributing to neural dysfunction and death is excitotoxicity. This process is based on the fact that the excessive glutamatereceptor stimulation may lead to neuronal damage. This overstimulation may be due to increased concentration of glutamate, or theprolonged activation of receptors.
PB Medknow Publications
SN 1876-7958
YR 2015
FD 2015
LK http://uvadoc.uva.es/handle/10324/45046
UL http://uvadoc.uva.es/handle/10324/45046
LA eng
NO Neural Regeneration Research, 2015, vol. 10, n. 9. p. 1371-1372
NO Producción Científica
DS UVaDOC
RD 21-dic-2024