RT info:eu-repo/semantics/article
T1 Heterologous humoral response against H5N1, H7N3, and H9N2 avian influenza viruses after seasonal vaccination in a european elderly opulation
A1 Sanz, Ivan
A1 Rojo Rello, Silvia
A1 Tamames, Sonia
A1 Eiros Bouza, José María
A1 Ortiz de Lejarazu Leonardo, Raúl
K1 Vacunación contra la influenza estacional
K1 Virus de la influenza aviar
K1 32 Ciencias Médicas
AB Avian influenza viruses are currently one of the main threats to human health in the world. Although there are some screening reports of antibodies against these viruses in humans from Western countries, most of these types of studies are conducted in poultry and market workers of Asian populations. The presence of antibodies against avian influenza viruses was evaluated in an elderly European population. An experimental study was conducted, including pre- and post-vaccine serum samples obtained from 174 elderly people vaccinated with seasonal influenza vaccines of 2006–2007, 2008–2009, 2009–2010, and 2010–2011 Northern Hemisphere vaccine campaigns. The presence of antibodies against A/H5N1, A/H7N3, and A/H9N2 avian influenza viruses were tested by using haemaglutination inhibition assays. Globally, heterotypic antibodies were found before vaccination in 2.9% of individuals against A/H5N1, 1.2% against A/H7N3, and 25.9% against A/H9N2. These pre-vaccination antibodies were present at titers ≥1/40 in 1.1% of individuals against A/H5N1, in 1.1% against H7N3, and in 0.6% against the A/H9N2 subtype. One 76 year-old male showed pre-vaccine antibodies (Abs) against those three avian influenza viruses, and another three individuals presented Abs against two different viruses. Seasonal influenza vaccination induced a significant number of heterotypic seroconversions against A/H5N1 (14.4%) and A/H9N2 (10.9%) viruses, but only one seroconversion was observed against the A/H7N3 subtype. After vaccination, four individuals showed Abs titers ≥1/40 against those three avian viruses, and 55 individuals against both A/H5N1 and A/H9N2. Seasonal vaccination is able to induce some weak heterotypic responses to viruses of avian origin in elderly individuals with no previous exposure to them. However, this response did not accomplish the European Medicament Agency criteria for influenza vaccine efficacy. The results of this study show that seasonal vaccines induce a broad response of heterotypic antibodies against avian influenza viruses, albeit at a low level
PB MDPI
SN 2076-393X
YR 2017
FD 2017
LK http://uvadoc.uva.es/handle/10324/45056
UL http://uvadoc.uva.es/handle/10324/45056
LA eng
NO Vaccines, 2017, vol. 5, n. 3, p. 17
NO Producción Científica
DS UVaDOC
RD 22-dic-2024