RT info:eu-repo/semantics/article
T1 Clinical and tear cytokine profiles after advanced surface ablation refractive surgery: A six-month follow-up
A1 González García, María Jesús
A1 Murillo, Giovanna M.
A1 Pinto Fraga, Francisco José
A1 García, Noelia
A1 Fernández Martínez, Itziar
A1 Maldonado López, Miguel José
A1 Calonge, Margarita
A1 Enriquez De Salamanca Aladro, Amalia
K1 Surface ablation
K1 Ablación en superficie
K1 Cytokines
K1 Citoquinas
K1 Dry eye disease
K1 Síndrome del ojo seco
K1 Ocular inflammation
K1 Inflamación ocular
K1 Refractive surgery
K1 Cirugía refractiva
AB Neuropathic dry eye is one of the most frequently seen complications after corneal refractive surgery, however, its incidence decreases in a significant manner along the first six months postoperative, reaching between 10 and 45% incidence. However, little is known on the inflammatory status of the ocular surface during this recovery process. We aim to analyze the clinical and tear molecule concentration changes along six months after advanced surface ablation for myopia correction, in a prospective study including 18 eyes of 18 subjects who bilaterally underwent advanced surface ablation corneal refractive surgery. Clinical variables (uncorrected distance visual acuity, symptoms, conjunctival hyperemia, tear osmolarity, tear stability, corneal fluorescein staining, conjunctival lissamine staining, Schirmer test, and corneal esthesiometry) and a panel of 23 pro and anti-inflammatory cytokines/chemokines concentration in tears preoperatively and at 1, 3 and 6 months postoperatively were evaluated. We found that uncorrected distance visual acuity improved significantly from baseline at 1-month visit, symptoms improved and tear osmolarity decreased significantly from baseline at 3-month visit and there was a decrease in mechanical corneal threshold between 1-month and 3- and 6-month visits. Regarding tear molecules, IL-4, IL-5, IL-6, IL-13, IL-17A, and IFN-γ tear levels were significantly increased at all the three visits, compared to preoperative levels at V0; IL-2 and VEGF were also significantly increased at 1-month and 6-month visits, but not at 3-month visit, whereas IL-9 IL-10 and IL-12 were only significantly increased at 6-month visit. Although we found that there is a recovery in clinical variables at 6 months postoperatively (i.e. neuropathic dry eye was not developed in the sample), ocular surface homeostasis is not completely restored, as it can be seen by the changes in concentration of some pro and anti-inflammatory molecules measured in tears.
PB Elsevier
SN 0014-4835
YR 2020
FD 2020
LK http://uvadoc.uva.es/handle/10324/45345
UL http://uvadoc.uva.es/handle/10324/45345
LA spa
NO Exp Eye Res  . 2020 Apr;193:107976
NO Producción Científica
DS UVaDOC
RD 25-nov-2024