RT info:eu-repo/semantics/article
T1 Molecular epidemiology of enterovirus 71, coxsackievirus A16 and A6 associated with hand, foot and mouth disease in Spain
A1 Barriuso Cabrerizo, María Rita
A1 Tarragó, D.
A1 Muñoz Almagro, C.
A1 Amo, E. del
A1 Dominguez-Gil González, Marta
A1 Eiros Bouza, José María
A1 López Miragaya, I.
A1 Pérez, C.
A1 Reina, J.
A1 Otero, A.
A1 González, I.
A1 Echevarría, J.E.
A1 Trallero, G.
K1 Epidemiología molecular
K1 Fiebre aftosa
K1 Enterovirus 71
K1 Coxsackievirus
K1 32 Ciencias Médicas
AB Hand, foot and mouth disease (HFMD) is a childhood illness frequently caused by genotypes belonging to the enterovirus A species,including coxsackievirus (CV)-A16 and enterovirus (EV)-71. Between 2010 and 2012, several outbreaks and sporadic cases of HFMDoccurred in different regions of Spain. The objective of the present study was to describe the enterovirus epidemiology associated withHFMD in the country. A total of 80 patients with HFMD or atypical rash were included. Detection and typing of the enteroviruses wereperformed directly in clinical samples using molecular methods. Enteroviruses were detected in 53 of the patients (66%). CV-A6 was themost frequent genotype, followed by CV-A16 and EV-71, but other minority types were also identified. Interestingly, during almost all of2010, CV-A16 was the only causative agent of HFMD but by the end of the year and during 2011, CV-A6 became predominant, whileCV-A16 was not detected. In 2012, however, both CV-A6 and CV-A16 circulated. EV-71 was associated with HFMD symptoms only inthree cases during 2012. All Spanish CV-A6 sequences segregated into one major genetic cluster together with other European and Asianstrains isolated between 2008 and 2011, most forming a particular clade. Spanish EV-71 strains belonged to subgenogroup C2, as did most ofthe European sequences circulated. In conclusion, the recent increase of HFMD cases in Spain and other European countries has been dueto a larger incidence of circulating species A enteroviruses, mainly CV-A6 and CV-A16, and the emergence of new genetic variants of theseviruses.
PB Elsevier
SN 1198-743X
YR 2014
FD 2014
LK http://uvadoc.uva.es/handle/10324/45372
UL http://uvadoc.uva.es/handle/10324/45372
LA eng
NO Clinical Microbiology and Infection,2014, vol. 20, n. 3, p. O150-O156
NO Producción Científica
DS UVaDOC
RD 06-ago-2024