RT info:eu-repo/semantics/article
T1 Development of Tropical Spastic Paraparesis in Human T-Lymphotropic Virus Type 1 Carriers Is Influenced by Interleukin 28B Gene Polymorphisms
A1 Treviño, Ana
A1 Lopez, Mariola
A1 Vispo, Eugenia
A1 Aguilera, Antonio
A1 Ramos, José M
A1 Benito, Rafael
A1 Roc, Lourdes
A1 Eiros Bouza, José María
A1 Mendoza, Carmen de
A1 Soriano, Vincent
K1 Alelos polimorfismo
K1 Virus
K1 Médula espinal
K1 32 Ciencias Médicas
AB Interleukin 28B (IL28B) rs12979860 polymorphisms were examined in 41 individuals with human T-lymphotrophic virus type 1 (HTLV-1). The alleles CT/TT were more frequent in 12 individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis than in 29 asymptomatic carriers (80% vs 20%; P = .03), and median HTLV-1 proviral load was greater in CT/TT than CC carriers (P = .01). Thus, IL28B testing and closer follow-up of HTLV-1 asymptomatic CT/TT carriers is warranted.
PB Oxford University Press
SN 1058-4838
YR 2012
FD 2012
LK http://uvadoc.uva.es/handle/10324/45386
UL http://uvadoc.uva.es/handle/10324/45386
LA eng
NO Clinical Infectious Diseases, 2012, vol. 55, n. 1, p. e1-e4
NO Producción Científica
DS UVaDOC
RD 22-dic-2024