RT info:eu-repo/semantics/article
T1 Nosocomial vs. community-acquired infective endocarditis in Spain: Location, trends, clinical presentation, etiology, and survival in the 21st Century
A1 Ortega Loubon, Christian Joseph
A1 Muñoz Moreno, María Fe
A1 Andrés García, Irene
A1 Álvarez González, Francisco Javier
A1 Gómez Sánchez, Esther
A1 Bustamante Munguira, Juan
A1 Lorenzo López, Mario
A1 Tamayo Velasco, Álvaro
A1 Jorge Monjas, Pablo
A1 Resino, Salvador
A1 Tamayo Gómez, Eduardo
A1 Heredia Rodríguez, María
K1 Infective endocarditis
K1 Endocarditis infecciosa
K1 Mortality
K1 Mortalidad
K1 Etiology
K1 Etiología
AB Major changes have occurred in the epidemiology and etiology of infective endocarditis (IE). Nevertheless, the differences between nosocomial infective endocarditis (NIE) and community-acquired infective endocarditis (CIE) have not been addressed in a population-based study. We conducted a retrospective, nationwide, temporal trend study from 1997 to 2014 analyzing the epidemiology, clinical, geographical, meteorological characteristics of patients diagnosed with IE in Spain, to distinguish NIE from CIE. Among 25,952 patients with IE (62.2 ± 18·6 years; 65.9% men), 45.9% had NIE. The incidence of IE increased from 2.83 to 3.73 due to the NIE incidence increment with a decline in CIE. Patients with NIE were older (63.8 years vs. 60.8 years, p < 0·001), presented a higher Charlson index (1.22 vs. 1.03, p < 0.001), a greater history of implanted cardiac devices (8.7% vs. 4.6%, p < 0.001), and higher mortality (31.5% vs. 21.7%, p < 0.001). The most frequent microorganism for both NIE and CIE was Staphylococcus (p < 0.001), and the North reported a higher incidence (p < 0.001). Risk factors of mortality for NIE were age, Charlson index, hemodialysis, shock, heart failure, and stroke. Risk factors for CIE included female sex, renal disease, and cardiac-device carriers. The etiology of IE shifted from community origins to mostly nosocomial-associated infections. Higher morbidity, mortality, and poorer outcomes are associated with NIE.
PB MDPI
SN 2077-0383
YR 2019
FD 2019
LK http://uvadoc.uva.es/handle/10324/45472
UL http://uvadoc.uva.es/handle/10324/45472
LA eng
NO Journal of Clinical Medicine, 2019, vol. 8, n. 10. 15 p.
NO Producción Científica
DS UVaDOC
RD 24-nov-2024