RT info:eu-repo/semantics/article
T1 Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study
A1 Jiménez Sousa, María Ángeles
A1 Liu, Pilar
A1 Medrano, Luz María
A1 Fernández Rodríguez, Amanda
A1 Almansa Mora, Raquel
A1 Gómez Sánchez, Esther
A1 Rico, Lucía
A1 Lorenzo López, Mario
A1 Fadrique, Alejandra
A1 Tamayo Gómez, Eduardo
A1 Resino, Salvador
K1 Polymorphism
K1 Polimorfismo
K1 Mortality
K1 Mortalidad
K1 Septic shock
K1 Choque séptico
K1 3213.01 Cirugía Abdominal
K1 3213.07 Cirugía del Corazón
AB The aim of this study was to investigate the relationship between the CD14 rs2569190 polymorphism and death related to septic shock in white European patients who underwent major cardiac or abdominal surgery. We carried out a retrospective study in 205 septic shock patients. The septic shock diagnosis was established by international consensus definitions. The outcome variable was the death within 28, 60 and 90 days after septic shock diagnosis. The CD14 rs2569190 polymorphism was analyzed by Agena Bioscience’s MassARRAY platform. For the genetic association analysis with survival was selected a recessive inheritance model (GG vs. AA/AG). One hundred thirteen out of 205 patients (55.1%) died with a survival median of 39 days (95%CI = 30.6; 47.4). Patients with rs2569190 GG genotype had shorter survival probability than rs2569190 AA/AG genotype at 60 days (62.3% vs 50%; p = 0.035), and 90 days (62.3% vs 52.6%; p = 0.046). The rs2569190 GG genotype was associated with increased risk of septic shock-related death in the first 60 days (adjusted hazard ratio (aHR) = 1.67; p = 0.016) and 90 days (aHR = 1.64; p = 0.020) compared to rs2569190 AA/AG genotype. In conclusion, the presence of CD14 rs2569190 GG genotype was associated with death in shock septic patients who underwent major surgery. Further studies with bigger sample size are required to verify this relationship.
PB Springer Nature
SN 2045-2322
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/45478
UL http://uvadoc.uva.es/handle/10324/45478
LA eng
NO Scientific Reports, 2018, vol. 8. 8 p.
NO Producción Científica
DS UVaDOC
RD 26-abr-2024