RT info:eu-repo/semantics/article
T1 Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplant
A1 Jiménez Sousa, María Ángeles
A1 Tamayo Gómez, Eduardo
A1 Guzmán Fulgencio, María
A1 Fernández Rodríguez, Amanda
A1 Heredia Rodríguez, María
A1 García Álvarez, Mónica
A1 Bermejo Martín, Jesús Francisco
A1 Pineda Tenor, Daniel
A1 Ruiz Granado, Patricia
A1 Álvarez Fuente, Elisa
A1 Gómez Sánchez, Esther
A1 Gómez Herreras, José Ignacio
A1 Resino, Salvador
K1 Kidney transplant
K1 Trasplante de riñón
K1 Allograft rejection
K1 Rechazo de aloinjerto
AB Mitochondrial DNA variants may contribute to differences in mitochondrial function, leading to an altered immune system. The aim of this study was to analyze the relationship between mtDNA haplogroups and the development of chronic allograft dysfunction in patients with kidney transplant. A retrospective observational study was carried out on 261 patients who received kidney transplant (114 had stable transplant and 147 patients developed chronic allograft dysfunction). DNA samples were genotyped for 14 mtDNA polymorphisms by using Sequenom's MassARRAY platform (San Diego, CA, USA). Only European white patients within the N macro-cluster were included. Patients with haplogroups V (odds ratio (OR)=0.32; p=0.037) and J (OR=0.36; p=0.038) showed lower odds for developing CRAD than patients with haplogroup H. After adjusting for the most significant variables, haplogroups V and J tended to statistical significance (p=0.091 and p=0.067 respectively). This is a preliminary study in which mtDNA haplogroups seem to be implicated in susceptibility or protection for developing chronic allograft dysfunction.
PB Ivyspring International Publisher
SN 1449-1907
YR 2014
FD 2014
LK http://uvadoc.uva.es/handle/10324/45532
UL http://uvadoc.uva.es/handle/10324/45532
LA eng
NO International Journal of Medical Sciences, 2014, vol. 11, n. 11. p. 1129-1132
NO Producción Científica
DS UVaDOC
RD 25-nov-2024