RT info:eu-repo/semantics/article
T1 Circulating neutrophil counts and mortality in septic shock
A1 Bermejo Martín, Jesús Francisco
A1 Tamayo Gómez, Eduardo
A1 Ruiz López del Prado, Gema
A1 Andaluz Ojeda, David
A1 Herrán Monge, Rubén
A1 Muriel Bombín, Arturo
A1 Muñoz Moreno, María Fe
A1 Heredia Rodríguez, María
A1 Citores, Rafael
A1 Gómez Herreras, José Ignacio
A1 Blanco Varela, Jesús
K1 Septic shock
K1 Choque séptico
K1 Validation cohort
K1 Cohorte de validación
K1 Endothelial damage
K1 Daño endotelial
AB Polynuclear neutrophils can play dual roles in sepsis:on the one hand they mediate major antimicrobialactivities and on the other hand they can contributeto the development of multiple organ failure [1].Nonetheless, in spite of the importance of these cellsin sepsis, the influence of the circulating neutrophilcount (CNC) on the prognosis of septic patients withthis pathology has not been properly evaluated.We analyzed the association between CNC and outcomein two cohorts of patients with diagnostic criteriaof septic shock (SS) [2]: the first was recruited in thecontext of a single center study (EXPRESS study, discoverycohort, n = 195; Table 1), and the second in the contextof a multi-centric study (GRECIA study, validationcohort, n = 194; Table 2). Written informed consent wasobtained from each patient or their legal representative.The two studies were approved by the Research EthicsCommittee of the Hospital Clínico Universitario, Valladolid,Spain (for the EXPRESS study) and Hospital UniversitarioRío Hortega, Valladolid, Spain (coordinatingcenter for the GRECIA study).
PB Springer Nature
SN 1364-8535
YR 2014
FD 2014
LK http://uvadoc.uva.es/handle/10324/45588
UL http://uvadoc.uva.es/handle/10324/45588
LA eng
NO Critical Care, 2014, vol. 18. 4 p.
NO Producción Científica
DS UVaDOC
RD 24-nov-2024